Young S, Haldane G
Department of Anaesthesia, Hairmyres Hospital, East Kilbride, UK.
Anaesthesia. 2006 Jun;61(6):593-6. doi: 10.1111/j.1365-2044.2006.04650.x.
We present the case of a 62-year-old man with severe cold agglutinin disease who underwent major colorectal surgery. Cold agglutinin disease is a condition in which auto-antibodies, usually immunoglobulin M, cause red blood cell agglutination at decreased body temperature. Haemolysis may result. Agglutination results in impaired perfusion, resulting in symptomatic Raynaud's phenomenon and acrocyanosis. Haemolysis can result in anaemia and thrombotic events caused by microvascular occlusion, in addition to haemoglobinuria and renal failure. Peri-operative hypothermia is common in all patients and may be associated with significant morbidity, but is potentially catastrophic in a patient suffering from cold agglutinin disease.
我们报告一例62岁患有严重冷凝集素病的男性患者接受了大肠大手术。冷凝集素病是一种自身抗体（通常为免疫球蛋白M）在体温降低时导致红细胞凝集的疾病。可能会发生溶血。凝集导致灌注受损，从而引发有症状的雷诺现象和手足发绀。溶血除了会导致血红蛋白尿和肾衰竭外，还会引起贫血以及由微血管闭塞导致的血栓形成事件。围手术期体温过低在所有患者中都很常见，可能会伴有严重的发病率，但对于患有冷凝集素病的患者来说可能是灾难性的。
