Al-Matham Khalid, Alabed Iehab, Zaidi Syed Z A, Qushmaq Khalid A
Department of Internal Medicine, Main Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
Ann Saudi Med. 2011 Mar-Apr;31(2):197-200. doi: 10.4103/0256-4947.76409.
Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia. Although it can occur secondary to lymphoproliferative disorders and autoimmune or infectious diseases, CAD is rarely reported as secondary to solid tumors. We report a case of a woman aged 18 years diagnosed with a well-differentiated hepatocellular carcinoma of the fibrolamellar subtype, who was shown to have CAD also. Her general condition, including CAD, improved after targeted therapy with sorafenib for the hepatocellular carcinoma and only conservative measures for the CAD that consisted of avoidance of cold. In summary, although it is an extremely rare association and less common than lymphoproliferative disorders, CAD can be associated with solid tumors.
冷凝集素病（CAD）是一种罕见的自身免疫性溶血性贫血。尽管它可继发于淋巴增殖性疾病、自身免疫性疾病或感染性疾病，但很少有CAD继发于实体瘤的报道。我们报告一例18岁女性，诊断为纤维板层型高分化肝细胞癌，同时也患有CAD。在针对肝细胞癌使用索拉非尼进行靶向治疗以及仅对CAD采取包括避免受寒在内的保守措施后，她的总体状况，包括CAD，有所改善。总之，尽管CAD与实体瘤的关联极为罕见，且不如与淋巴增殖性疾病的关联常见，但CAD可与实体瘤相关。
