Annesi-Maesano I, Beyer A, Marmouz F, Mathelier-Fusade P, Vervloet D, Bauchau V
INSERM, UMR-S 707, Medical School Saint-Antoine, University Pierre et Marie Curie-Paris 6, 75012 Paris, France.
Br J Dermatol. 2006 Jun;154(6):1128-36. doi: 10.1111/j.1365-2133.2006.07186.x.
Psychological comorbidity is a known aspect of allergic disease. However, there is recent evidence that a large proportion of allergic patients remains undiagnosed and untreated for psychological disease. In addition, the complexities of the anxiety-allergy relationship, i.e. differences for current and past disease, or differences among allergic disease types, are not well understood.
To measure the level of anxiety in a large allergic population in France using a standardized measure, the State/Trait Anxiety Inventory (STAI).
Allergy patients in France (n = 3939) who visited their allergy specialists participated in the study. The patients completed a questionnaire which was then linked to the questionnaire completed by their physician. Only patients with both subject and physician questionnaire were kept in the analyses. Mean STAI scores for the State (S) and Trait (T) scales were obtained for each allergic disease. ANCOVA models testing group differences on the mean scores, using the categories "current disease", "past disease" and "allergic disease ever", were assessed along with relevant confounders.
Allergic rhinitis (AR), asthma and atopic dermatitis (AD) were the most prevalent conditions of the 12 allergic diseases assessed in the study. Women had higher mean STAI S/T scores than men and age was also found to be associated with higher S scores; therefore, both age and gender were included as covariates where relevant. A single ANCOVA model for each STAI scale showed a statistical difference among the various allergic diseases. Using the category "current disease" each allergic disease was assessed separately regarding the presence or absence of that disease. Higher, statistically significant mean STAI scores were found for AD and allergic urticaria on the S scale and for AD on the T scale. Similarly, for the category "allergic disease ever", AD and allergic urticaria reached statistical significance on the S scale, while on the T scale only AD was statistically significant. When patients were assessed for anxiety based on their past disease, asthma, AR and sinusitis were significant on the S scale while asthma and nasal polyps were statistically significant on the T scale. When asthma and AD were tested simultaneously, only the latter was significant.
High mean scores for State and Trait anxiety were mostly associated with AD.
心理共病是过敏性疾病的一个已知方面。然而，最近有证据表明，很大一部分过敏患者的心理疾病仍未得到诊断和治疗。此外，焦虑与过敏关系的复杂性，即当前疾病和既往疾病的差异，或过敏性疾病类型之间的差异，尚未得到充分理解。
使用标准化测量工具状态/特质焦虑量表（STAI）来测量法国大量过敏人群的焦虑水平。
法国3939名就诊于过敏专科医生的过敏患者参与了该研究。患者完成一份问卷，然后将其与医生填写的问卷关联起来。分析中仅保留同时有患者和医生问卷的患者。针对每种过敏性疾病，获得状态（S）量表和特质（T）量表的平均STAI分数。使用“当前疾病”“既往疾病”和“曾患过敏性疾病”类别，对平均分数的组间差异进行协方差分析模型测试，并评估相关混杂因素。
变应性鼻炎（AR）、哮喘和特应性皮炎（AD）是该研究评估的12种过敏性疾病中最常见的疾病。女性的平均STAI S/T分数高于男性，年龄也与较高的S分数相关；因此，在相关情况下，年龄和性别均作为协变量纳入。每个STAI量表的单个协方差分析模型显示，各种过敏性疾病之间存在统计学差异。使用“当前疾病”类别，分别评估每种过敏性疾病是否存在该疾病。在S量表上，AD和过敏性荨麻疹的平均STAI分数较高且具有统计学意义，在T量表上，AD的分数具有统计学意义。同样，对于“曾患过敏性疾病”类别，AD和过敏性荨麻疹在S量表上具有统计学意义，而在T量表上只有AD具有统计学意义。当根据患者的既往疾病评估焦虑时，哮喘、AR和鼻窦炎在S量表上具有统计学意义，而哮喘和鼻息肉在T量表上具有统计学意义。当同时测试哮喘和AD时，只有后者具有统计学意义。
状态焦虑和特质焦虑的平均高分大多与AD相关。
