Hashizume H, Horibe T, Ohshima A, Ito T, Yagi H, Takigawa M
Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu, Japan.
Br J Dermatol. 2005 Jun;152(6):1161-4. doi: 10.1111/j.1365-2133.2005.06449.x.
Stress, which mediates anxiety, worsens skin symptoms in patients with atopic dermatitis (AD). The contribution of anxiety to immune dysfunction, which plays a critical role in the pathogenesis of AD, requires clarification.
To examine the relationship between anxiety and atopy-relevant immune function in AD.
Eighty-five patients with AD and 58 normal individuals without a history of allergic disorders were enrolled in this study. To assess anxiety, the state-trait anxiety inventory was completed for both groups. In the AD group, measurements were made of SCORAD scores, serum IgE levels, itching (visual analogue scale), blood eosinophil count and T-helper (Th) 1/Th2 ratio in the peripheral blood.
Anxiety was significantly higher among the subjects with AD than the normal subjects, and trait anxiety (TA) was higher than state anxiety (SA) in the AD group. Serum total IgE levels were correlated positively with TA and the TA/SA ratio and inversely with SA, and the Th1/Th2 ratio was correlated inversely with TA and the TA/SA ratio.
The patients with AD had higher anxiety levels than normal individuals, and those with a stronger perception of TA than SA showed enhanced serum IgE synthesis and Th2 shifting.
压力介导焦虑，会加重特应性皮炎（AD）患者的皮肤症状。焦虑对免疫功能障碍的影响在AD发病机制中起关键作用，这一点尚需阐明。
研究AD患者焦虑与特应性相关免疫功能之间的关系。
本研究纳入了85例AD患者和58例无过敏疾病史的正常个体。两组均完成状态-特质焦虑量表以评估焦虑情况。对AD组患者进行SCORAD评分、血清IgE水平、瘙痒程度（视觉模拟评分）、血液嗜酸性粒细胞计数及外周血辅助性T细胞（Th）1/Th2比值的测定。
AD患者的焦虑水平显著高于正常受试者，且AD组中特质焦虑（TA）高于状态焦虑（SA）。血清总IgE水平与TA及TA/SA比值呈正相关，与SA呈负相关，Th1/Th2比值与TA及TA/SA比值呈负相关。
AD患者的焦虑水平高于正常个体，且特质焦虑感强于状态焦虑感的患者血清IgE合成增加，Th2偏移增强。
