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半自动动态视野计进行暗点测绘:刺激特性和受试者反应速度的影响

Scotoma mapping by semi-automated kinetic perimetry: the effects of stimulus properties and the speed of subjects' responses.

作者信息

Dolderer Jan, Vonthein Reinhard, Johnson Chris A, Schiefer Ulrich, Hart William

机构信息

Department of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, Tübingen, Germany.

出版信息

Acta Ophthalmol Scand. 2006 Jun;84(3):338-44. doi: 10.1111/j.1600-0420.2005.00624.x.

Abstract

PURPOSE

The study aimed firstly to determine the effects of stimulus variables on the detection of a scotoma border and, secondly, to study the reproducibility of the method during semi-automated kinetic perimetry.

METHODS

The size of the physiological blind spot in 18 young normal subjects was measured with a video-campimetric device, the Tübingen computer campimeter (TCC). Kinetic stimuli of two different sizes and at four different levels of luminance were presented. Examinations were repeated within 2 weeks. Measurements were corrected for individual response times and the area of the blind spot was computed. The effects of stimulus strength and size and the repeatability of blind spot measurements were evaluated by an analysis of variance.

RESULTS

The physiological blind spot showed significant inter- and intraindividual variations in size (least square means ranging from 17 to 49 square degrees), with a standard deviation of 6.8 square degrees. The measured size of the blind spot increased as a function of decreasing stimulus value, by reducing either the relative brightness or the size of stimuli. Use of a correction for each subject's speed of responses nearly halved the level of random variance. The temporal sequence of measurements (the order in which they were performed) had no apparent effect on the calculated values of blind spot size.

CONCLUSIONS

Semi-automated kinetic perimetry can determine the size of the physiological blind spot with good repeatability in young, normal subjects. Determination of each individual's speed of response and inclusion of this variable in the calculations reduced variance of the measure significantly. This study confirmed the presence of considerable interindividual differences in the size of the physiological blind spot.

摘要

目的

本研究的首要目的是确定刺激变量对暗点边界检测的影响,其次是研究半自动动态视野检查法的可重复性。

方法

使用视频视野计——图宾根计算机视野计(TCC)测量18名年轻正常受试者的生理盲点大小。呈现两种不同大小和四种不同亮度水平下的动态刺激。在2周内重复进行检查。对测量结果进行个体反应时间校正,并计算盲点面积。通过方差分析评估刺激强度和大小的影响以及盲点测量的可重复性。

结果

生理盲点大小在个体间和个体内均存在显著差异(最小二乘均值范围为17至49平方度),标准差为6.8平方度。随着刺激值的降低,即通过降低相对亮度或刺激大小,所测量的盲点大小增加。对每个受试者的反应速度进行校正后,随机方差水平几乎减半。测量的时间顺序(执行测量的顺序)对计算出的盲点大小值没有明显影响。

结论

半自动动态视野检查法能够在年轻正常受试者中良好地重复确定生理盲点的大小。确定每个个体的反应速度并将该变量纳入计算可显著降低测量的方差。本研究证实了生理盲点大小在个体间存在相当大的差异。

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