Nevalainen J, Paetzold J, Krapp E, Vonthein R, Johnson C A, Schiefer U
University Eye Hospital Oulu, Oulu, Finland.
Graefes Arch Clin Exp Ophthalmol. 2008 Sep;246(9):1331-9. doi: 10.1007/s00417-008-0828-1. Epub 2008 Jun 18.
(i) To compare visual field (VF) results obtained with semi-automated kinetic perimetry (SKP) and automated static perimetry (ASP) in patients with advanced glaucomatous VF loss, (ii) to evaluate test-retest reliability of SKP and ASP and (iii) to assess patients' preference for SKP and ASP.
Twenty eyes of 20 patients (11 male, 9 female, aged 38 to 83 years) with advanced glaucomatous VF loss (stage III or IV according to the Aulhorn classification). Each of the 20 patients were examined in 4 sessions every 3 months with SKP (Goldmann stimulus III4e, I4e and at least one additional dimmer stimulus, within the 90 degrees visual field) and ASP within the 30 degrees VF, employing a threshold-related, supra-threshold test strategy with high spatial resolution for the same instrument (Octopus 101 perimeter, Haag-Streit Inc., Koeniz, Switzerland).
Visual field areas (VFA) were compared by analyses of covariance (ANCOVA) with co-variable time, patient effect and their interaction. Test-retest reliability was assessed by ratios (R) of intersection and union of VFA: The mean VFA within the 30 degrees of VF at baseline was 2,344 square degrees (deg(2)) with SKP (Goldmann stimulus III4e) and 1,844 deg(2) with ASP. The patients showed stable visual fields for both SKP and ASP. Comparison of SKP with ASP of the same sessions revealed a median ratio of intersection and union of VFA of 0.78 with the III4e stimulus and of 0.79 with the I4e stimulus. When follow-up SKPs were compared with baseline SKPs the median of the ratios was between 0.80 and 0.93 for the different isopters. The corresponding ratio of ASP's follow-up and baseline VFs was 0.81 (with the size III static stimulus). Nineteen of 20 patients preferred kinetic perimetry to static perimetry.
The comparability between SKP and ASP is satisfactory and within the range of the test-retest reliability of ASP. SKP shows slightly better test-retest reliability than ASP. The majority of patients with advanced glaucomatous visual field loss prefer SKP instead of ASP. SKP is a valuable alternative to ASP in monitoring advanced glaucomatous visual field loss.
(i)比较晚期青光眼视野缺损患者使用半自动动态视野计(SKP)和自动静态视野计(ASP)所获得的视野(VF)结果;(ii)评估SKP和ASP的重测信度;(iii)评估患者对SKP和ASP的偏好。
20例患者(11例男性,9例女性,年龄38至83岁)的20只眼睛患有晚期青光眼视野缺损(根据Aulhorn分类为III期或IV期)。20例患者中的每一位均每3个月接受4次检查,分别使用SKP(Goldmann刺激III4e、I4e以及至少一种额外的较暗刺激,在90度视野范围内)和ASP在30度视野范围内进行检查,对同一台仪器(Octopus 101视野计,Haag-Streit公司,瑞士科尼茨)采用与阈值相关的超阈值测试策略且具有高空间分辨率。
通过协方差分析(ANCOVA)对视野区域(VFA)进行比较,协变量包括时间、患者效应及其交互作用。通过VFA的交集和并集的比率(R)评估重测信度:在基线时,30度视野范围内的平均VFA,SKP(Goldmann刺激III4e)为2344平方度(deg²),ASP为1844 deg²。患者的SKP和ASP视野均显示稳定。同一次检查中SKP与ASP的比较显示,使用III4e刺激时VFA的交集和并集的中位数比率为0.78,使用I4e刺激时为0.79。当将随访的SKP与基线SKP进行比较时,不同等视线的比率中位数在0.80至0.93之间。ASP随访与基线视野的相应比率为0.81(使用III号大小的静态刺激)。20例患者中有19例更喜欢动态视野计而非静态视野计。
SKP与ASP之间的可比性令人满意,且在ASP的重测信度范围内。SKP显示出比重测信度略好于ASP。大多数晚期青光眼视野缺损患者更喜欢SKP而非ASP。在监测晚期青光眼视野缺损方面,SKP是ASP的一种有价值的替代方法。