Hanincová Klára, Kurtenbach Klaus, Diuk-Wasser Maria, Brei Brandon, Fish Durland
Yale University, New Haven, Connecticut, USA.
Emerg Infect Dis. 2006 Apr;12(4):604-11. doi: 10.3201/eid1204.051016.
We examined the degree of host specialization of different strains of Borrelia burgdorferi, the tickborne pathogen that causes Lyme borreliosis in the northeastern United States. We first assessed the genetic population structures of B. burgdorferi in ticks obtained from different mammalian host species and in questing ticks sampled in a woodland ecosystem in Connecticut. By comparing the patterns found in our study with data from another cross-sectional study, we demonstrate that B. burgdorferi is a generalist microparasite and conclude that efficient cross-species transmission of B. burgdorferi is a key feature that has allowed the rapid spread of Lyme borreliosis across the northeastern United States.
我们研究了不同菌株的伯氏疏螺旋体的宿主专一化程度,该蜱传病原体在美国东北部引发莱姆病。我们首先评估了从不同哺乳动物宿主物种采集的蜱以及在康涅狄格州一个森林生态系统中采集的觅食蜱体内伯氏疏螺旋体的遗传种群结构。通过将我们研究中发现的模式与另一项横断面研究的数据进行比较,我们证明伯氏疏螺旋体是一种泛寄性微寄生虫,并得出结论,伯氏疏螺旋体高效的跨物种传播是莱姆病在美国东北部迅速传播的一个关键特征。