新型猪流感病毒H3N1亚型，美国
Novel swine influenza virus subtype H3N1, United States.
作者信息
Lekcharoensuk Porntippa, Lager Kelly M, Vemulapalli Ramesh, Woodruff Mary, Vincent Amy L, Richt Jürgen A
机构信息
Virus and Prion Disease of Livestock Research Unit, National Animal Disease Center, US Department of Agriculture/ARS, 2300 Dayton Avenue, Ames, IA 50010, USA.
出版信息
Emerg Infect Dis. 2006 May;12(5):787-94. doi: 10.3201/eid1205.051060.
Influenza A virus infects various animal species and transmits among different hosts, especially between humans and swine. Swine may serve as a mixing vessel to create new reassortants that could infect humans. Thus, monitoring and characterizing influenza viruses in swine are important in preventing interspecies transmission. We report the emergence and characterization of a novel H3N1 subtype of swine influenza virus (SIV) in the United States. Phylogenetic analysis showed that the H3N1 SIVs may have acquired the hemagglutinin gene from an H3N2 turkey isolate, the neuraminidase gene from a human H1N1 isolate, and the remaining genes from currently circulating SIVs. The H3N1 SIVs were antigenically related to the turkey virus. Lung lesions and nasal shedding occurred in swine infected with the H3N1 SIVs, suggesting the potential to transmit among swine and to humans. Further surveillance will help determine whether this novel subtype will continue to circulate in swine populations.
甲型流感病毒感染多种动物物种，并在不同宿主之间传播，尤其是在人类和猪之间。猪可能充当一个混合容器，产生能够感染人类的新重配病毒。因此，监测和鉴定猪流感病毒对于预防种间传播很重要。我们报告了美国一种新型H3N1亚型猪流感病毒（SIV）的出现和特征。系统发育分析表明，H3N1 SIVs可能从一株H3N2火鸡分离株获得了血凝素基因，从一株人类H1N1分离株获得了神经氨酸酶基因，其余基因则来自目前正在流行的SIVs。H3N1 SIVs与火鸡病毒存在抗原相关性。感染H3N1 SIVs的猪出现了肺部病变和鼻腔排毒，表明其有可能在猪之间以及向人类传播。进一步的监测将有助于确定这种新型亚型是否会继续在猪群中传播。
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