荷马蛋白：对神经精神疾病的影响。

Homer proteins: implications for neuropsychiatric disorders.

作者信息

Szumlinski Karen K, Kalivas Peter W, Worley Paul F

机构信息

Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106-9660, USA.

出版信息

Curr Opin Neurobiol. 2006 Jun;16(3):251-7. doi: 10.1016/j.conb.2006.05.002. Epub 2006 May 15.

DOI:10.1016/j.conb.2006.05.002

PMID:16704932

Abstract

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

摘要

除了维持和调节边缘-皮质-纹状体脑区的细胞外谷氨酸水平外，荷马蛋白还调节信号转导、突触形成和受体运输。越来越多的临床前观察结果表明，即时早期基因荷马异构体和组成型表达的荷马异构体在与神经精神疾病相关的行为病理学中具有潜在作用，如成瘾和/或酗酒、抑郁症、焦虑症、癫痫和精神分裂症。