糖基磷脂酰肌醇锚定的CD4/Thy-1嵌合分子在人细胞而非小鼠细胞中充当人类免疫缺陷病毒受体，并受神经节苷脂调节。
Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides.
作者信息
Jasin M, Page K A, Littman D R
机构信息
Beckman Center, Department of Biochemistry, Stanford Medical Center, California 94305.
出版信息
J Virol. 1991 Jan;65(1):440-4. doi: 10.1128/JVI.65.1.440-444.1991.
Abstract
Human and mouse cell lines that expressed a CD4/Thy-1 fusion protein on the cell surface were constructed and tested for the capacity to be infected with human immunodeficiency virus. The human cell lines, in contrast to the mouse line, were infectable. The CD4/Thy-1 fusion, which is anchored to the membrane by a glycosylphosphatidylinositol tail rather than a peptide linkage, can therefore serve as a human immunodeficiency virus receptor. In addition, this molecule, like CD4, is down-modulated in its cell surface expression by exogenous gangliosides.
摘要
构建了在细胞表面表达CD4/Thy-1融合蛋白的人和小鼠细胞系，并检测了它们感染人类免疫缺陷病毒的能力。与小鼠细胞系不同，人细胞系可被感染。因此，通过糖基磷脂酰肌醇尾部而非肽键锚定在膜上的CD4/Thy-1融合蛋白可作为人类免疫缺陷病毒受体。此外，该分子与CD4一样，其细胞表面表达会被外源性神经节苷脂下调。
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