使用二氯甲烷进行新型、通用且实用的烯胺环丙烷化反应。
New, general, and practical enamine cyclopropanation using dichloromethane.
作者信息
Tsai Chia-Chung, Hsieh I-Lin, Cheng Tsung-Ting, Tsai Ping-Kuei, Lin Kuo-Wei, Yan Tu-Hsin
机构信息
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, Republic of China.
出版信息
Org Lett. 2006 May 25;8(11):2261-3. doi: 10.1021/ol0604365.
PMID:16706501
Abstract
[reaction: see text] Dichloromethane serves as a novel electrophilic carbene equivalent which adds to an enamine double bond. The presence of other alkene moieties in the enamine partner is well tolerated. Even enamines derived from sterically hindered ketones react readily with dichloromethane promoted by TiCl(4)-Mg.
摘要
[反应：见正文] 二氯甲烷作为一种新型的亲电卡宾等价物，可加成到烯胺双键上。烯胺分子中其他烯烃部分的存在能很好地耐受。甚至由空间位阻酮衍生的烯胺也能在TiCl(4)-Mg促进下与二氯甲烷顺利反应。
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