Mocchegiani Eugenio, Costarelli Laura, Giacconi Robertina, Cipriano Catia, Muti Elisa, Rink Lothar, Malavolta Marco
Immunology Centre, Nutrition, Immunity, and Aging Section, INRCA Research Department, Ancona, Italy.
Rejuvenation Res. 2006 Summer;9(2):351-4. doi: 10.1089/rej.2006.9.351.
Proteins involved in zinc homeostasis may be altered in aging. This phenomenon may lead to zinc deficiency in the peripheral blood and an accumulation of zinc bound to insoluble aggregates at the extracellular level in the brain. Therefore, it should be more correct to talk about aging as a condition associated with zinc dyshomeostasis rather than deficiency. Restoring functional zinc homeostasis in aging people is an attractive field for antiaging research, but requires further knowledge than the current state of the art.
参与锌稳态的蛋白质在衰老过程中可能会发生改变。这种现象可能导致外周血锌缺乏以及大脑细胞外水平与不溶性聚集体结合的锌积累。因此，将衰老描述为与锌稳态失衡相关的状况而非锌缺乏更为恰当。恢复老年人的功能性锌稳态是抗衰老研究中一个有吸引力的领域，但需要比当前技术水平更多的知识。
