Carmody Thomas J, Rush A John, Bernstein Ira H, Brannan Stephen, Husain Mustafa M, Trivedi Madhukar H
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9086, USA.
J Affect Disord. 2006 Oct;95(1-3):115-8. doi: 10.1016/j.jad.2006.03.024. Epub 2006 May 16.
The ability to convert total scores from one scale to another facilitates the interpretation of research findings and facilitates the use of systematic measurement in clinical practice.
Item Response Theory methods were used to convert total scores between the 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16) and the Montgomery Asberg Depression Rating Scale (MADRS) total scores. Data were obtained from a sample of 233 outpatients with highly treatment-resistant, nonpsychotic major depressive episodes participating in a one-year open label study of vagus nerve stimulation to augment psychotropic medication treatment.
MADRS total scores averaged 31.9 (SD = 6.7) at baseline and 21.9 (SD = 11.0) at one year. QIDS-SR16 total scores averaged 17.6 (SD = 3.6) at baseline and 12.5 (SD = 5.8) at one year. Based on one-year data (or exit if the patient did not complete one year), corresponding QIDS-SR16 and MADRS total scores were presented for each possible QIDS-SR16 and MADRS total score. A QIDS-SR16 total score of 5 was comparable to a MADRS total score of 7 or 8 (7.5).
The degree to which these results generalize to less treatment-resistant samples is unknown.
The conversion of QIDS-SR16 and MADRS total scores provides a basis for clinicians who wish to use the QIDS-SR16 to understand what MADRS total scores reported in clinical trials approximate QIDS-SR16 total scores obtained with their patients.
将一个量表的总分转换为另一个量表的总分，有助于研究结果的解读，并便于在临床实践中使用系统测量方法。
采用项目反应理论方法，在16项抑郁症状快速量表（QIDS-SR16）总分与蒙哥马利-阿斯伯格抑郁评定量表（MADRS）总分之间进行转换。数据来自233名对治疗高度抵抗的非精神病性重度抑郁发作门诊患者，这些患者参与了一项为期一年的迷走神经刺激增强精神药物治疗的开放标签研究。
基线时MADRS总分平均为31.9（标准差=6.7），一年时为21.9（标准差=11.0）。基线时QIDS-SR16总分平均为17.6（标准差=3.6），一年时为12.5（标准差=5.8）。根据一年的数据（如果患者未完成一年治疗，则为退出时的数据），列出了每个可能的QIDS-SR16和MADRS总分对应的QIDS-SR16和MADRS总分。QIDS-SR16总分5相当于MADRS总分7或8（7.5）。
这些结果在多大程度上适用于治疗抵抗性较低的样本尚不清楚。
QIDS-SR16和MADRS总分的转换为希望使用QIDS-SR16的临床医生提供了一个依据，以便他们了解临床试验中报告的MADRS总分与他们患者获得的QIDS-SR16总分相近。
