Galinowski A, Lehert P
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Hôpital Sainte Anne, Paris, France.
Int Clin Psychopharmacol. 1995 Sep;10(3):157-61. doi: 10.1097/00004850-199510030-00004.
In order to assess the internal structure of MADRS, a principal component analysis was performed in a group of 137 patients suffering from DSM-III major depression (MADRS score at baseline > 20) receiving a 4 week treatment in three double-blind drug trials (medifoxamine vs clomipramine, imipramine or amineptine). Prior to antidepressant treatment, three factors could be identified with 32 %, 12 % and 11.5 % of explained variance. The first factor corresponded to the global severity of depression whereas the second, with sleep and appetite items scoring high, could be postulated as a somatic factor. After 28 days of antidepressant treatment (mean MADRS total score = 13.3), only one factor could be substantiated, representing 66% of total variance. The study was primarily based on data obtained without rotation, which ensures the independence of the different factors. The good internal consistency of MADRS accounts for the high correlation of all items with the first factor (r = 0.95). MADRS appears as a unidimensional scale more oriented towards psychic as opposed to somatic aspects of depression.
为评估蒙哥马利-艾森伯格抑郁量表（MADRS）的内部结构，在三项双盲药物试验（甲磺酸吗氯贝胺与氯米帕明、丙咪嗪或阿密替林对比）中，对137例患有DSM-III重度抑郁症（基线时MADRS评分>20）且接受4周治疗的患者进行了主成分分析。在抗抑郁治疗前，可识别出三个因素，其解释方差分别为32%、12%和11.5%。第一个因素对应抑郁的整体严重程度，而第二个因素在睡眠和食欲项目上得分较高，可假定为躯体因素。经过28天的抗抑郁治疗（MADRS总分均值 = 13.3）后，仅能证实一个因素，占总方差的66%。该研究主要基于未经旋转获得的数据，这确保了不同因素的独立性。MADRS良好的内部一致性解释了所有项目与第一个因素的高度相关性（r = 0.95）。MADRS表现为一个更侧重于抑郁心理而非躯体方面的单维量表。
