Huo Y, Guo C, Zhang Q-Y, Chen W-S, Zheng H-C, Rahman K, Qin L-P
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Phytomedicine. 2007 Feb;14(2-3):143-6. doi: 10.1016/j.phymed.2006.03.008. Epub 2006 May 16.
This investigation was undertaken to ascertain the antinociceptive activity of Caragana microphylla Lam. seeds and isolate and characterize the constituents. Antinociceptive activity was screened using acetic acid-induced abdominal constriction in ICR mice. The 75% ethanol extract and some fractions showed analgesic activity, but the antinociceptive activity of chloroform fraction was the strongest and was more productive than other fractions. Seven compounds were isolated from it and identified as: (1) machaeric acid, (2) beta-sitosterol, (3) stigmasterol, (4) pratol, (5) dehydrocavidine, (6) formononetin and (7) sucrose. Caragana microphylla Lam. seeds showed analgesic activity, with the chloroform fraction showing the strongest analgesic activity among the fractions.
本研究旨在确定小叶锦鸡儿种子的抗伤害感受活性，并分离和鉴定其成分。采用醋酸诱导ICR小鼠腹部收缩的方法筛选抗伤害感受活性。75%乙醇提取物和一些馏分显示出镇痛活性，但氯仿馏分的抗伤害感受活性最强，且比其他馏分更有效。从中分离出七种化合物，分别鉴定为：(1) 羽扇豆酸，(2) β-谷甾醇，(3) 豆甾醇，(4) 普拉托醇，(5) 脱氢卡维丁，(6) 芒柄花素和(7) 蔗糖。小叶锦鸡儿种子显示出镇痛活性，其中氯仿馏分在各馏分中镇痛活性最强。
