Rysz Jacek, Bartnicki Piotr, Błaszczak Robert, Kujawski Krzysztof, Ciałkowska-Rysz Aleksandra, Olszewski Robert, Markuszewski Leszek
Uniwersytet Medyczny w Lodzi, Uniwersytecki Szpital Kliniczny Nr 2.
Pol Merkur Lekarski. 2006 Feb;20(116):180-3.
Release of prostaglandin E2 (PGE2) and leukotrien B4 (LTB4) in vitro by resting and PHA-stimulated peripheral blood mononuclear cells (PBMNC) in the presence of three concentrations of myoinositol (30, 300, 600 micromol/l) was investigated.
We examinated 10 uremic patients on regular hemodialysis treatment and 10 healthy subjects (control group).
Release of PGE2 and LTB4 by resting and PHA-stimulated PBMNC was significantly lower in the presence of myoinositol in concentrations generally obserwed in the blood serum of chronic uraemic patients on regular hemodialysis treatment (600 micromol/l) in both investigated groups, while it remained unchanged in the presence of myoinositol in the concentration observed in normal blood serum (30 micromol/l).
The results seem to indicate that myoinositol, in the concentrations found in uremic blood serum, may possibly exert antiinflammatory actions.
研究在三种浓度（30、300、600微摩尔/升）的肌醇存在下，静息和PHA刺激的外周血单个核细胞（PBMNC）在体外释放前列腺素E2（PGE2）和白三烯B4（LTB4）的情况。
我们检查了10名接受定期血液透析治疗的尿毒症患者和10名健康受试者（对照组）。
在两个研究组中，在慢性尿毒症患者定期血液透析治疗血清中通常观察到的浓度（600微摩尔/升）的肌醇存在下，静息和PHA刺激的PBMNC释放PGE2和LTB4显著降低，而在正常血清中观察到的浓度（30微摩尔/升）的肌醇存在下，其释放保持不变。
结果似乎表明，尿毒症血清中发现的浓度的肌醇可能具有抗炎作用。
