β-肾上腺素能受体激动剂治疗可逆转去神经支配小鼠腓肠肌的失神经萎缩，并增强胶原蛋白增殖。

Beta-adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle.

作者信息

Kumar Rakesh, Katoch Surender S, Sharma Sushma

机构信息

Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla 171 005, India.

出版信息

Indian J Exp Biol. 2006 May;44(5):371-6.

DOI:

PMID:16708889

Abstract

Daily oral administration of isoproterenol hydrochloride (60 mg/kg body weight; for 30 days) a beta-receptor agonist to normal innervated and denervated adult male Swiss albino mice confirmed its ability to induce skeletal muscle hypertrophy and reverse denervation atrophy respectively. Measurement of total tissue proteins and dry muscle mass showed 15-17% increase with 6% rise of hypertrophy index in gastrocnemius muscle. Hydroxyproline assay employed to measure the total tissue collagen exhibited 45% increase in collagen in normal innervated gastrocnemius muscle in response to beta agonist treatment. beta-adrenoceptor agonist ameliorated denervation atrophy along with further increase in collagen content of denervated gastrocnemius muscle.

摘要

对正常支配和去神经支配的成年雄性瑞士白化小鼠每日口服盐酸异丙肾上腺素（60毫克/千克体重，持续30天），这是一种β受体激动剂，证实了它分别诱导骨骼肌肥大和逆转去神经萎缩的能力。对总组织蛋白和肌肉干重的测量显示，腓肠肌中总组织蛋白增加了15 - 17%，肥大指数上升了6%。用于测量总组织胶原蛋白的羟脯氨酸测定显示，在β激动剂治疗后，正常支配的腓肠肌中胶原蛋白增加了45%。β肾上腺素能激动剂改善了去神经萎缩，同时去神经支配的腓肠肌中胶原蛋白含量进一步增加。