Téllez-Avila Félix Ignacio, García-Osogobio Sandra Minerva
Departamentos de Medicina Interna, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Rev Invest Clin. 2005 Nov-Dec;57(6):814-9.
The carcinoembryonic antigen (CEA) is glycoprotein localized in the apical surface of mature enterocytes. The members of the CEA gene family are clustered on chromosome 19q13.2. It is formed by 29 genes, of which 18 are expressed. Many functions of CEA have been known in healthy indiuiduals, however its role as cell adhesion molecule is the most studied. Besides the colon, CEA is expressed in the stomach, tongue, oesophagus, cervix, and prostate. The most important clinical function is in colorectal, gastric and ovary cancer. It is used as prognosis marker, staging system, recurrence, treatment response and liver metastases. There are many non-neoplasic diseases that enhance CEA value. Actually, CEA is being studying as target of immunotherapy.
癌胚抗原（CEA）是一种糖蛋白，定位于成熟肠上皮细胞的顶端表面。CEA基因家族的成员聚集在19号染色体q13.2区域。它由29个基因组成，其中18个基因表达。在健康个体中，CEA的许多功能已为人所知，然而其作为细胞粘附分子的作用研究得最多。除了结肠，CEA还在胃、舌、食管、宫颈和前列腺中表达。最重要的临床作用在于结直肠癌、胃癌和卵巢癌。它被用作预后标志物、分期系统、复发、治疗反应和肝转移的指标。有许多非肿瘤性疾病会使CEA值升高。实际上，CEA正作为免疫治疗的靶点进行研究。
