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肺炎克雷伯菌3型菌毛表达所需mrk决定簇的核苷酸序列及功能

Nucleotide sequence and functions of mrk determinants necessary for expression of type 3 fimbriae in Klebsiella pneumoniae.

作者信息

Allen B L, Gerlach G F, Clegg S

机构信息

Department of Microbiology, University of Iowa, Iowa City 52242.

出版信息

J Bacteriol. 1991 Jan;173(2):916-20. doi: 10.1128/jb.173.2.916-920.1991.

DOI:10.1128/jb.173.2.916-920.1991
PMID:1670938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC207091/
Abstract

The nucleotide sequence of six genes involved in the expression of type 3 fimbriae of Klebsiella pneumoniae was determined. In addition to the genes that encode the fimbrial subunit (mrkA) and adhesion (mrkD), the mrkB, mrkC, and mrkE genes appear to be involved in assembly of the fimbrial filament and regulation of type 3 fimbrial expression. The mrkF gene product is required to maintain the stability of the fimbrial filament on the cell surface.

摘要

测定了肺炎克雷伯菌3型菌毛表达所涉及的6个基因的核苷酸序列。除了编码菌毛亚基（mrkA）和黏附素（mrkD）的基因外，mrkB、mrkC和mrkE基因似乎参与菌毛丝的组装以及3型菌毛表达的调控。mrkF基因产物是维持菌毛丝在细胞表面稳定性所必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/207091/99f3d23f24a7/jbacter00092-0513-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/207091/e95fad2ffd2e/jbacter00092-0512-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/207091/99f3d23f24a7/jbacter00092-0513-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/207091/e95fad2ffd2e/jbacter00092-0512-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/626b/207091/99f3d23f24a7/jbacter00092-0513-a.jpg

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