Landtblom A-M, Tondel M, Hjalmarsson P, Flodin U, Axelson O
Department of Neuroscience and Locomotion, Division of Neurology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Occup Environ Med. 2006 Jun;63(6):387-9. doi: 10.1136/oem.2005.024604.
Previous studies have suggested that exposure to organic solvents, including volatile anaesthetic agents, may be a risk factor for multiple sclerosis (MS), possibly in combination with genetic and other environmental factors.
To further investigate the role of volatile anaesthetic agents having similar acute toxic effects to other organic solvents.
Female nurse anaesthetists, other female nurses, and female teachers from middle and upper compulsory school levels were identified and retrieved from the 1985 census, Statistics Sweden. By means of the unique personal identity number in Sweden, these individuals were linked with the disability pension registers at The National Social Insurance Board and also with data on hospital care 1985-2000 at The National Board of Health and Welfare.
The cumulative incidence rate ratio of MS was found to be increased in female nurse anaesthetists in relation to other nurses (statistically not significant) and teachers (statistically significant), respectively.
These findings give some support to previous findings of an increased risk for MS in nurse anaesthetists. This is interesting in the context of previous observations of organic solvents in general as a potential risk factor in MS.
先前的研究表明，接触有机溶剂，包括挥发性麻醉剂，可能是多发性硬化症（MS）的一个风险因素，可能与遗传和其他环境因素共同作用。
进一步研究与其他有机溶剂具有相似急性毒性作用的挥发性麻醉剂的作用。
从瑞典统计局1985年人口普查中识别并检索女性麻醉护士、其他女性护士以及初中和高中女教师。通过瑞典独特的个人身份号码，将这些人与国家社会保险局的残疾抚恤金登记册以及国家卫生和福利委员会1985 - 2000年的医院护理数据相联系。
发现女性麻醉护士中MS的累积发病率相对于其他护士（统计学上无显著差异）和教师（统计学上有显著差异）有所增加。
这些发现为先前关于麻醉护士患MS风险增加的研究结果提供了一些支持。鉴于先前观察到有机溶剂总体上是MS的潜在风险因素，这一发现很有趣。
