Miller Juli P, Stadanlick Jason E, Cancro Michael P
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
J Immunol. 2006 Jun 1;176(11):6405-10. doi: 10.4049/jimmunol.176.11.6405.
The BLyS family of ligands and receptors governs B cell homeostasis by controlling survival, differentiation, and lifespan. This family consists of multiple receptors and ligands, allowing independent regulation of different B cell subsets by varying the combination and levels of receptors expressed. Multiple downstream signaling pathways are implicated in these activities, reflecting this receptor complexity as well as cross-talk with other B cell signaling systems. BLyS levels are associated with multiple forms of humoral autoimmunity and can modulate tolerogenic elimination at the transitional checkpoint. BLyS responsiveness thus balances peripheral selection against cell numbers, providing an elastic system that varies selective stringency based on homeostatic demands.
BLyS配体和受体家族通过控制B细胞的存活、分化和寿命来维持B细胞的稳态。该家族由多种受体和配体组成，通过改变表达的受体组合和水平，能够对不同的B细胞亚群进行独立调节。多种下游信号通路参与这些活动，这既反映了该受体的复杂性，也体现了其与其他B细胞信号系统的相互作用。BLyS水平与多种形式的体液自身免疫相关，并且能够在过渡检查点调节耐受性清除。因此，BLyS反应性在针对细胞数量的外周选择之间取得平衡，提供了一个基于稳态需求而改变选择严格性的弹性系统。
