Thurnau G R, Payne G G
Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City.
Int J Gynaecol Obstet. 1991 Jan;34(1):21-5. doi: 10.1016/0020-7292(91)90533-b.
On the basis of normative data from non-diabetic gravidae, the daytime glucose profile (DGP) is introduced as a model for insulin management of diabetes mellitus in pregnancy. The DGP employs four preprandial (target level = 70 mg/dl) and three 1-h postprandial glucose determinations (target level = 140 mg/dl). Insulin changes are based on a simple equation applied to individual glucose value difference between the patient (P) and target (T) levels (P - T/20). With the aid of this model, the average (+/- SD) of the daytime mean plasma glucose (DMG) levels of 22 pregnant women requiring insulin treatment (183 +/- 36 mg/dl) approached normalization (114 +/- 15 mg/dl) after 2-7 profile determinations (median = 3.5).
基于非糖尿病孕妇的标准数据，引入日间血糖谱（DGP）作为妊娠期糖尿病胰岛素管理的模型。DGP采用四次餐前血糖测定（目标水平 = 70mg/dl）和三次餐后1小时血糖测定（目标水平 = 140mg/dl）。胰岛素剂量调整基于一个简单公式，该公式应用于患者（P）血糖值与目标（T）水平之间的个体差异（P - T/20）。借助该模型，22名需要胰岛素治疗的孕妇日间平均血浆葡萄糖（DMG）水平的平均值（±标准差）（183±36mg/dl）在进行2 - 7次血糖谱测定后（中位数 = 3.5）接近正常水平（114±15mg/dl）。
