Galadari Ibrahim, Sheriff Mohamed Omar
Department of Dermatology, Faculty of Medicine and Health Sciences, United Arab Emirates University.
Eur Ann Allergy Clin Immunol. 2006 Feb;38(2):55-8.
Scabies is a pruritic dermatosis due to infestation by a mite that stimulates both humoral and cellular immune responses causing cutaneous lesions as well as pruritus. Changes in immune response pattern with treatment are associated with improvement in symptoms and clinical cure. In this study, we analysed the cellular infiltrate types and patterns in lesions of Scabies. Treated patients were divided into 2 groups as those with and without pruritus. In the pre-treatment cases, there was a high incidence of T3, T4, T6 and T8 infiltration in the lesions, with T4 greater than T8. Following treatment, it was noted that T8 density was significantly increased in patients who had resolution of symptoms. It can therefore be concluded that T4 cell dominance is the cause of persistant itching and T8 increase leads to improvement in the pruritus.
疥疮是一种由螨虫感染引起的瘙痒性皮肤病，螨虫会刺激体液免疫和细胞免疫反应，导致皮肤损伤和瘙痒。治疗过程中免疫反应模式的变化与症状改善和临床治愈相关。在本研究中，我们分析了疥疮皮损中的细胞浸润类型和模式。将接受治疗的患者分为有瘙痒和无瘙痒两组。在治疗前的病例中，皮损中T3、T4、T6和T8浸润的发生率较高，T4多于T8。治疗后，注意到症状缓解的患者中T8密度显著增加。因此可以得出结论，T4细胞占优势是持续瘙痒的原因，T8增加导致瘙痒改善。
