Brinkmeier T, Herbst R A, Frosch P J
Department of Dermatology, Klinikum Dortmund gGmbH, and University of Witten/Herdecke, Beurhausstrasse 40, D-44137 Dortmund, Germany.
J Eur Acad Dermatol Venereol. 2004 Sep;18(5):588-90. doi: 10.1111/j.1468-3083.2004.00978.x.
Reactive perforating collagenosis (RPC) in adults commonly manifests in patients with diabetes mellitus. Pruritus and consequent induced scratching have been identified as the bases for the evolution of this skin disease. We present the unusual case of a 55-year-old female diabetic with characteristic umbilicated skin lesions and a long history of scabies. Histology from a crusty nodule revealed transepidermal elimination of collagen. Following antiscabietic treatment, two courses of oral doxycycline demonstrated beneficial effects in controlling the perforating skin disorder.
成人反应性穿通性胶原病（RPC）常见于糖尿病患者。瘙痒及随之而来的搔抓已被确认为这种皮肤病演变的基础。我们报告了一例不寻常的病例，一名55岁的女性糖尿病患者，有典型的脐状皮肤病变且有长期疥疮病史。一个结痂结节的组织学检查显示有胶原的表皮穿通性消除。经过抗疥疮治疗后，两个疗程的口服多西环素在控制这种穿通性皮肤病方面显示出有益效果。
