Erazo Silvia, Delporte Carla, Negrete Rosa, García Rubén, Zaldívar Mercedes, Iturra Gladys, Caballero Esther, López José Luis, Backhouse Nadine
Department of Pharmacological and Toxicological Chemistry, School of Chemical and Pharmaceutical Sciences, University of Chile, P.O. Box 233, Santiago 1, Chile.
J Ethnopharmacol. 2006 Oct 11;107(3):395-400. doi: 10.1016/j.jep.2006.03.028. Epub 2006 Apr 15.
The folk medicine employs Schinus polygamus to treat arthritic pain and cleansing of wounds. As no reports of pharmacological studies supporting its anti-inflammatory and analgesic properties, extracts of increasing polarity were assayed on the base of fever, pain and inflammation, together with its antimicrobial activity. All the extracts showed pharmacological activities. From the most active extracts different metabolites were isolated that can in part explain the antipyretic, anti-inflammatory, and analgesic activity: beta-sitosterol, shikimic acid together with quercetin, previously reported. Also, the essential oil of leaves and fruits was obtained and compared with the oil obtained from Schinus polygamus collected in Argentine. Oils differed in composition and in antibacterial activity, where the Chilean species exhibited a wide spectrum of activity against Gram-positive and Gram-negative bacteria, and the most abundant compound found in leaves and fruits was beta-pinene, meanwhile the Argentine species showed high activity against Bacillus cereus, and the main components resulted to be alpha-phellandrene and limonene.
民间医学用多花胡椒治疗关节疼痛和伤口清洁。由于没有支持其抗炎和镇痛特性的药理学研究报告，因此基于发热、疼痛和炎症以及其抗菌活性，对极性递增的提取物进行了测定。所有提取物均显示出药理活性。从活性最强的提取物中分离出了不同的代谢物，这些代谢物可以部分解释其解热、抗炎和镇痛活性：β-谷甾醇、莽草酸以及之前报道过的槲皮素。此外，还获得了叶和果实的精油，并与从阿根廷采集的多花胡椒中获得的精油进行了比较。两种精油在成分和抗菌活性上存在差异，其中智利的品种对革兰氏阳性菌和革兰氏阴性菌表现出广泛的活性，叶和果实中发现的最丰富的化合物是β-蒎烯，而阿根廷的品种对蜡样芽孢杆菌表现出高活性，其主要成分是α-水芹烯和柠檬烯。
