Murray Peter J
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Curr Opin Pharmacol. 2006 Aug;6(4):379-86. doi: 10.1016/j.coph.2006.01.010. Epub 2006 May 18.
Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is only beginning to be understood and could be a way to regulate inflammation by pharmacological agents.
白细胞介素（IL）-10在负向调节炎症中发挥着不可替代的作用，主要通过一种选择性阻断编码细胞因子、趋化因子、细胞表面分子及其他参与炎症传播的分子的促炎基因表达的机制来实现。不出所料，IL-10作为调节炎症性疾病的工具已引起关注。然而，IL-10作为抗炎剂的临床应用并未达到预期。尽管如此，IL-10受体用于产生抗炎反应的信号通路才刚刚开始被了解，这可能是通过药物制剂调节炎症的一种方式。
