Casasco A, Calligaro A, Casasco M, Springall D R, Polak J M, Marchetti C
Institute of Histology and Embryology, University of Pavia, Italy.
J Dent Res. 1991 Feb;70(2):87-9. doi: 10.1177/00220345910700021601.
Specific antiserum to somatostatin was used for the immunocytochemical detection of this neuropeptide in human dental pulp. Immunoreactive axon varicosities were observed in the radicular as well as coronal pulp. Fibers displaying somatostatin-like immunoreactivity were detectable within radicular nerve trunks and were found to be associated mainly with blood vessels. Nevertheless, positive fibers with no apparent relation to blood vessels were also observed. No pulp cell was found to be immunoreactive. Previous physiological studies demonstrated that somatostatin may function as a regulatory peptide in feline dental pulp via a pre-synaptic inhibition of substance P release from sensory nerve terminals. It is tempting to speculate that such a mechanism may also be effective in human teeth and may be of value in the regulation of pulpal blood flow and in situations when sensory nerve fibers are activated, e.g., during pulpal inflammation.
生长抑素特异性抗血清用于免疫细胞化学检测人牙髓中的这种神经肽。在根尖和冠髓中均观察到免疫反应性轴突膨体。在根尖神经干内可检测到显示生长抑素样免疫反应性的纤维，并且发现其主要与血管相关。然而，也观察到与血管无明显关系的阳性纤维。未发现牙髓细胞具有免疫反应性。先前的生理学研究表明，生长抑素可能通过对感觉神经末梢P物质释放的突触前抑制作用，在猫牙髓中作为一种调节肽发挥作用。很容易推测，这样的机制在人类牙齿中可能也有效，并且在调节牙髓血流以及感觉神经纤维被激活的情况下（例如在牙髓炎症期间）可能具有重要意义。
