Ballard Clive, Howard Robert
Medical Research Council Centre for Neurodegeneration Research, King's College London, De Crespigny Park, London SE5 8AF, UK.
Nat Rev Neurosci. 2006 Jun;7(6):492-500. doi: 10.1038/nrn1926.
Neuroleptic (antipsychotic) drugs are often used to treat psychiatric symptoms frequently seen in dementia, but their use is controversial. We present a new meta-analysis to assess the efficacy of these drugs for the treatment of psychiatric symptoms in Alzheimer's disease, and discuss the more limited evidence for their potential benefits in other dementias. We recommend that these treatments be limited to the short-term treatment of psychiatric symptoms associated with serious distress or risk.
抗精神病药物常用于治疗痴呆症中常见的精神症状，但其使用存在争议。我们进行了一项新的荟萃分析，以评估这些药物治疗阿尔茨海默病精神症状的疗效，并讨论其在其他痴呆症中潜在益处的更有限证据。我们建议，这些治疗应仅限于对伴有严重痛苦或风险的精神症状进行短期治疗。
