Raskind M A, Risse S C, Lampe T H
J Clin Psychiatry. 1987 May;48 Suppl:16-8.
Introduced in the 1950s, antipsychotic agents have been found to improve symptomatology and function in young and middle-aged psychotic schizophrenics. Three decades of research, however, have not made clear these agents' usefulness in demented elderly patients. A review of placebo-controlled studies suggests a definite but limited role for antipsychotic medication in behaviorally disturbed elderly dementia patients with agitated behavior. Studies also suggest that cognitive function needs careful monitoring when these drugs are prescribed to treat behavioral symptoms of dementia.
抗精神病药物于20世纪50年代问世，已被发现可改善年轻及中年精神分裂症患者的症状及功能。然而，三十年的研究仍未明确这些药物在老年痴呆患者中的效用。一项对安慰剂对照研究的综述表明，抗精神病药物在伴有激越行为的老年痴呆行为障碍患者中具有明确但有限的作用。研究还表明，在使用这些药物治疗痴呆的行为症状时，需要仔细监测认知功能。
