Hayakawa Katsumi, Shiozaki Toshiki, Yamamoto Akira, Kubo Soichi, Osako Tsutomu
Departments of Radiology, Kyoto City Hospital, Japan.
Radiat Med. 2006 Feb;24(2):128-32. doi: 10.1007/BF02493279.
A prospective double-blind randomized study was performed to compare the contrast of vascular enhancement using three dosages of iodinated contrast media for a possible metastatic lesion in the brain.
Sixty-six patients with lung cancer received brain computed tomography (CT) with intravenous administration of iodinated contrast medium (CM). The patients were randomly assigned to receive one of the three types of CM: 30 g iodine, 24 g iodine, and 15 g iodine. Three radiologists judged the degree of vascular contrast enhancement and diagnosed the presence of brain metastasis. The CT numbers in major arteries were also measured.
The subjective average scores with standard deviation were 2.06+/-0.48, 1.97+/-048, and 1.44+/-0.43, and the measured average CT numbers with standard deviation (SD) were 168.5+/-39.6, 166.1+/-28.6, and 146.1+/-27.0 HU with 30 g, 24 g, and 15 g iodine, respectively. The scores and the CT numbers in 15 g iodine were less than those with 30 g and 24 g iodine. Brain metastasis was detected in one patient each in groups A and C, and one false-positive case was found in group B.
CT study with a dose of 24 g iodine showed equivalent quality on vascular enhancement in comparison with a 30 g iodine dose.
进行一项前瞻性双盲随机研究，以比较三种剂量的碘化造影剂用于脑内可能的转移病灶时血管强化的对比度。
66例肺癌患者接受了静脉注射碘化造影剂（CM）的脑部计算机断层扫描（CT）。患者被随机分配接受三种类型的CM之一：30克碘、24克碘和15克碘。三名放射科医生判断血管造影增强程度并诊断脑转移的存在。还测量了主要动脉的CT值。
标准差的主观平均得分分别为2.06±0.48、1.97±0.48和1.44±0.43，测量的平均CT值及标准差（SD）分别为30克碘时168.5±39.6、24克碘时166.1±28.6和15克碘时146.1±27.0HU。15克碘组的得分和CT值低于30克碘组和24克碘组。A组和C组各有1例患者检测到脑转移，B组发现1例假阳性病例。
24克碘剂量的CT研究在血管强化方面显示出与30克碘剂量相当的质量。
