杂合子家族性高胆固醇血症年轻女性的早发性心血管疾病
Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia.
作者信息
van der Graaf Anouk, Hutten Barbara A, Kastelein John J P, Vissers Maud N
机构信息
Academic Medical Centre, Dept.Vascular Medicine, Meibergdreef 9 (room F4-159.2) 1105 AZ, Amsterdam, The Netherlands.
出版信息
Expert Rev Cardiovasc Ther. 2006 May;4(3):345-51. doi: 10.1586/14779072.4.3.345.
Heterozygous familial hypercholesterolemia is associated with elevated low-density lipoprotein cholesterol levels and the development of premature cardiovascular disease. Despite this general statement, data regarding the incidence of cardiovascular disease in young women with familial hypercholesterolemia are lacking. In this review, information of age-specific incidence, risk factors and therapeutic avenues in women with heterozygous familial hypercholesterolemia are discussed.
杂合子家族性高胆固醇血症与低密度脂蛋白胆固醇水平升高及早发性心血管疾病的发生有关。尽管有这一普遍说法，但关于家族性高胆固醇血症年轻女性心血管疾病发病率的数据却很缺乏。在这篇综述中，我们讨论了杂合子家族性高胆固醇血症女性的年龄特异性发病率、危险因素及治疗途径的相关信息。
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