Tsoumakidou Maria, Siafakas Nikolaos M
Department of Thoracic Medicine, Medical School, University of Crete, Greece.
Respir Res. 2006 May 22;7(1):80. doi: 10.1186/1465-9921-7-80.
Airway inflammation increases during acute exacerbations of COPD. Extrinsic factors, such as airway infections, increased air pollution, and intrinsic factors, such as increased oxidative stress and altered immunity may contribute to this increase. The evidence for this and the potential mechanisms by which various aetiological agents increase inflammation during COPD exacerbations is reviewed. The pathophysiologic consequences of increased airway inflammation during COPD exacerbations are also discussed. This review aims to establish a cause and effect relationship between etiological factors of increased airway inflammation and COPD exacerbations based on recently published data. Although it can be speculated that reducing inflammation may prevent and/or treat COPD exacerbations, the existing anti-inflammatory treatments are modestly effective.
慢性阻塞性肺疾病（COPD）急性加重期气道炎症会加重。外在因素，如气道感染、空气污染增加，以及内在因素，如氧化应激增加和免疫改变，都可能导致这种炎症加重。本文综述了这方面的证据以及各种病因在COPD加重期增加炎症的潜在机制。还讨论了COPD加重期气道炎症加重的病理生理后果。本综述旨在根据最近发表的数据，建立气道炎症加重的病因与COPD加重之间的因果关系。尽管可以推测减轻炎症可能预防和/或治疗COPD加重，但现有的抗炎治疗效果有限。
