Tada Y, Fujitani T, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Ogata A, Kamimura H
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
Food Chem Toxicol. 2006 Aug;44(8):1408-13. doi: 10.1016/j.fct.2006.03.006. Epub 2006 Mar 30.
Tetrabromobisphenol A (TBBPA), brominated flame retardant, is produced in the largest amounts globally for use in plastics or building materials. TBBPA has been detected in sediment, air at the dismantling plant or human serum samples. In the present study, we examined the effects of prenatal and postnatal exposure to TBBPA in mice. TBBPA (99.1% pure) in diet was administered to pregnant ICR mice at doses of 0% (control), 0.01%, 0.1% or 1.0% from gestational day 0 to weaning at postnatal day 27. The average daily food intake and body weight of dams showed no significant differences between the control and treated groups. There were no dose-related effects on reproductive data. Serum concentrations of total-cholesterol and liver weights of treated dams and offspring were higher than those of the control mice. Histological findings in treated dams or offspring showed the increase of focal necrosis of hepatocytes and inflammatory cell infiltration in the liver, and increase of dilation or atrophy of renal tubules and cyst in the kidney. TBBPA was developed as a new, safe class of flame retardant and was not highly toxic. However, the present data suggested that TBBPA caused a lipid metabolic disorder and hepatic or kidney lesion, under these conditions.
四溴双酚A（TBBPA）是一种溴化阻燃剂，全球产量最大，用于塑料或建筑材料。在沉积物、拆解厂的空气中或人体血清样本中都检测到了TBBPA。在本研究中，我们检测了产前和产后暴露于TBBPA对小鼠的影响。从妊娠第0天到出生后第27天断奶，以0%（对照）、0.01%、0.1%或1.0%的剂量将饮食中的TBBPA（纯度99.1%）给予怀孕的ICR小鼠。对照组和处理组之间，母鼠的平均每日食物摄入量和体重没有显著差异。对生殖数据没有剂量相关影响。处理组母鼠和后代的血清总胆固醇浓度和肝脏重量高于对照小鼠。处理组母鼠或后代的组织学结果显示，肝细胞局灶性坏死增加，肝脏中有炎性细胞浸润，肾小管扩张或萎缩以及肾脏囊肿增加。TBBPA作为一种新型的安全阻燃剂而研发，毒性不高。然而，目前的数据表明，在这些条件下，TBBPA会导致脂质代谢紊乱以及肝脏或肾脏病变。
