Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States.
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States; ReproTox Biotech LLC, Athens 30602, GA, United States.
Reprod Toxicol. 2018 Aug;79:96-123. doi: 10.1016/j.reprotox.2018.06.005. Epub 2018 Jun 18.
Known endocrine disruptor bisphenol A (BPA) has been shown to be a reproductive toxicant in animal models. Its structural analogs: bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) are increasingly being used in consumer products. However, these analogs may exert similar adverse effects on the reproductive system, and their toxicological data are still limited. This mini-review examined studies on both BPA and BPA analog exposure and reproductive toxicity. It outlines the current state of knowledge on human exposure, toxicokinetics, endocrine activities, and reproductive toxicities of BPA and its analogs. BPA analogs showed similar endocrine potencies when compared to BPA, and emerging data suggest they may pose threats as reproductive hazards in animal models. While evidence based on epidemiological studies is still weak, we have utilized current studies to highlight knowledge gaps and research needs for future risk assessments.
已知内分泌干扰物双酚 A（BPA）已被证明是动物模型中的生殖毒物。其结构类似物：双酚 S（BPS）、双酚 F（BPF）、双酚 AF（BPAF）和四溴双酚 A（TBBPA）越来越多地被用于消费产品。然而，这些类似物可能对生殖系统产生类似的不良影响，其毒理学数据仍然有限。本迷你综述检查了 BPA 和 BPA 类似物暴露与生殖毒性的研究。它概述了目前关于 BPA 及其类似物的人类暴露、毒代动力学、内分泌活性和生殖毒性的知识状况。与 BPA 相比，BPA 类似物表现出相似的内分泌效力，新出现的数据表明，它们可能对动物模型中的生殖危害构成威胁。虽然基于流行病学研究的证据仍然薄弱，但我们利用当前的研究来突出未来风险评估的知识空白和研究需求。
