双酚 A 及其类似物对生殖健康的影响：小型综述。
Effects of bisphenol A and its analogs on reproductive health: A mini review.
机构信息
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States.
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States; ReproTox Biotech LLC, Athens 30602, GA, United States.
出版信息
Reprod Toxicol. 2018 Aug;79:96-123. doi: 10.1016/j.reprotox.2018.06.005. Epub 2018 Jun 18.
Abstract
Known endocrine disruptor bisphenol A (BPA) has been shown to be a reproductive toxicant in animal models. Its structural analogs: bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) are increasingly being used in consumer products. However, these analogs may exert similar adverse effects on the reproductive system, and their toxicological data are still limited. This mini-review examined studies on both BPA and BPA analog exposure and reproductive toxicity. It outlines the current state of knowledge on human exposure, toxicokinetics, endocrine activities, and reproductive toxicities of BPA and its analogs. BPA analogs showed similar endocrine potencies when compared to BPA, and emerging data suggest they may pose threats as reproductive hazards in animal models. While evidence based on epidemiological studies is still weak, we have utilized current studies to highlight knowledge gaps and research needs for future risk assessments.
摘要
已知内分泌干扰物双酚 A（BPA）已被证明是动物模型中的生殖毒物。其结构类似物：双酚 S（BPS）、双酚 F（BPF）、双酚 AF（BPAF）和四溴双酚 A（TBBPA）越来越多地被用于消费产品。然而，这些类似物可能对生殖系统产生类似的不良影响，其毒理学数据仍然有限。本迷你综述检查了 BPA 和 BPA 类似物暴露与生殖毒性的研究。它概述了目前关于 BPA 及其类似物的人类暴露、毒代动力学、内分泌活性和生殖毒性的知识状况。与 BPA 相比，BPA 类似物表现出相似的内分泌效力，新出现的数据表明，它们可能对动物模型中的生殖危害构成威胁。虽然基于流行病学研究的证据仍然薄弱，但我们利用当前的研究来突出未来风险评估的知识空白和研究需求。
相似文献
1
Effects of bisphenol A and its analogs on reproductive health: A mini review.双酚 A 及其类似物对生殖健康的影响：小型综述。
Reprod Toxicol. 2018 Aug;79:96-123. doi: 10.1016/j.reprotox.2018.06.005. Epub 2018 Jun 18.
2
Bisphenol AF and Bisphenol F Induce Similar Feminizing Effects in Chicken Embryo Testis as Bisphenol A.双酚 AF 和双酚 F 像双酚 A 一样对鸡胚睾丸产生类似的雌性化效应。
Toxicol Sci. 2020 Dec 1;178(2):239-250. doi: 10.1093/toxsci/kfaa152.
3
Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances.双酚 A 的替代物：替代物质的致癌性、生殖毒性和内分泌干扰潜力的综述。
Crit Rev Toxicol. 2020 Feb;50(2):128-147. doi: 10.1080/10408444.2019.1701986. Epub 2020 Feb 7.
4
Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells.双酚类似物对H295R细胞中类固醇生成基因表达和激素合成的影响。
Chemosphere. 2016 Mar;147:9-19. doi: 10.1016/j.chemosphere.2015.12.081. Epub 2016 Jan 2.
5
A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.双酚 A（BPA）结构类似物和功能替代品的健康和毒理学活性的范围综述。
Toxicology. 2019 Aug 1;424:152235. doi: 10.1016/j.tox.2019.06.006. Epub 2019 Jun 12.
6
Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes.双酚S和双酚F：双酚A替代品激素活性的系统评价与比较
Environ Health Perspect. 2015 Jul;123(7):643-50. doi: 10.1289/ehp.1408989. Epub 2015 Mar 16.
7
Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis.同时评估双酚 A 及其几种类似物对成人睾丸的影响。
Hum Reprod. 2017 Jul 1;32(7):1465-1473. doi: 10.1093/humrep/dex093.
8
Prenatal BPA and its analogs BPB, BPF, and BPS exposure and reproductive axis function in the male offspring of Sprague Dawley rats.产前双酚 A 及其类似物 BPB、BPF 和 BPS 暴露与 Sprague Dawley 大鼠雄性后代生殖轴功能。
Hum Exp Toxicol. 2019 Dec;38(12):1344-1365. doi: 10.1177/0960327119862335.
9
High-Content Image-Based Single-Cell Phenotypic Analysis for the Testicular Toxicity Prediction Induced by Bisphenol A and Its Analogs Bisphenol S, Bisphenol AF, and Tetrabromobisphenol A in a Three-Dimensional Testicular Cell Co-culture Model.基于高内涵成像的单细胞表型分析用于预测双酚 A 及其类似物双酚 S、双酚 AF 和四溴双酚 A 在三维睾丸细胞共培养模型中的睾丸毒性。
Toxicol Sci. 2020 Feb 1;173(2):313-335. doi: 10.1093/toxsci/kfz233.
10
Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues.动物模型中由于双酚 A 类似物暴露导致的神经内分泌干扰。
Front Neuroendocrinol. 2017 Oct;47:123-133. doi: 10.1016/j.yfrne.2017.08.001. Epub 2017 Aug 8.
引用本文的文献
1
Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro.破坏防御机制：双酚A及其类似物对人体体外抗体产生的影响
Life (Basel). 2025 Jul 28;15(8):1203. doi: 10.3390/life15081203.
2
Effects of Pharmaceuticals and Endocrine-Disrupting Chemicals on Reproductive Biology of Aquatic Fauna: Penguins as Sentinel Species.药物和内分泌干扰化学物质对水生动物生殖生物学的影响：企鹅作为指示物种
J Xenobiot. 2025 Jul 4;15(4):110. doi: 10.3390/jox15040110.
3
Bisphenol-A disrupts mitochondrial functionality leading to senescence and apoptosis in human amniotic mesenchymal stromal cells.双酚A破坏线粒体功能，导致人羊膜间充质基质细胞衰老和凋亡。
Cell Death Discov. 2025 Jul 16;11(1):327. doi: 10.1038/s41420-025-02620-8.
4
Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.柚皮苷对双酚A诱导的公鸡神经和生殖系统氧化应激损伤的治疗作用
Vet Med Sci. 2025 Jul;11(4):e70322. doi: 10.1002/vms3.70322.
5
Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A.基于暴露于乙炔雌二醇和双酚A的鸡胚和LMH 3D球体的雌激素受体激动作用不良结局途径的鸟类特异性证据。
Environ Sci Technol. 2025 Jun 3;59(21):10136-10144. doi: 10.1021/acs.est.4c10887. Epub 2025 May 18.
6
Mechanisms of bisphenol A and its analogs as endocrine disruptors via nuclear receptors and related signaling pathways.双酚A及其类似物作为内分泌干扰物通过核受体及相关信号通路发挥作用的机制。
Arch Toxicol. 2025 Mar 21. doi: 10.1007/s00204-025-04025-z.
7
Bisphenol-S exposure of zebrafish unveils the hidden risks of bisphenol paradigm with growth, developmental, and behavioral impacts similar to bisphenol-A.斑马鱼暴露于双酚S揭示了双酚类物质的潜在风险，其对生长、发育和行为的影响与双酚A类似。
Sci Rep. 2025 Mar 20;15(1):9560. doi: 10.1038/s41598-025-91984-z.
8
Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review.揭开吲哚 - 3 - 甲醇和二吲哚甲烷的多方面药理作用：综述
Plants (Basel). 2025 Mar 6;14(5):827. doi: 10.3390/plants14050827.
9
The deleterious effect of bisphenol S on early embryo development of mice.双酚S对小鼠早期胚胎发育的有害影响。
Hormones (Athens). 2025 Mar 4. doi: 10.1007/s42000-025-00638-2.
10
Impact of Endocrine Disruptors on the Genitourinary Tract.内分泌干扰物对泌尿生殖道的影响。
J Xenobiot. 2024 Dec 2;14(4):1849-1888. doi: 10.3390/jox14040099.
本文引用的文献
1
Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis.双酚A（BPA）对睾丸间质细胞增殖和运动影响所涉及的信号：一项比较蛋白质组学分析
Toxicol Res (Camb). 2016 Sep 13;5(6):1573-1584. doi: 10.1039/c6tx00258g. eCollection 2016 Nov 1.
2
Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA.美国生产和使用双酚 A（BPA）的行业工人的尿液双酚 A（BPA）浓度。
Ann Work Expo Health. 2017 Mar 1;61(2):164-182. doi: 10.1093/annweh/wxw021.
3
Assessment of Occupational Exposure to Bisphenol A in Five Different Production Companies in Finland.评估芬兰五家不同生产公司中双酚 A 的职业暴露情况。
Ann Work Expo Health. 2017 Jan 1;61(1):44-55. doi: 10.1093/annweh/wxw006.
4
Long-term exposure to a 'safe' dose of bisphenol A reduced protein acetylation in adult rat testes.长期暴露于“安全”剂量的双酚 A 会降低成年大鼠睾丸中的蛋白质乙酰化水平。
Sci Rep. 2017 Jan 9;7:40337. doi: 10.1038/srep40337.
5
Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome.多囊卵巢综合征不孕女性中的双酚A与卵巢储备功能
Int J Environ Res Public Health. 2016 Dec 27;14(1):18. doi: 10.3390/ijerph14010018.
6
The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity.由活性氧触发的PERK/EIF2α/chop途径对细胞凋亡的调节在双酚A诱导的雄性生殖毒性中起着至关重要的作用。
Toxicol Appl Pharmacol. 2017 Jan 1;314:98-108. doi: 10.1016/j.taap.2016.11.013. Epub 2016 Nov 25.
7
Environmental and occupational exposure to bisphenol A and endometriosis: urinary and peritoneal fluid concentration levels.环境和职业性双酚A暴露与子宫内膜异位症：尿液和腹腔液中的浓度水平
Int Arch Occup Environ Health. 2017 Jan;90(1):49-61. doi: 10.1007/s00420-016-1171-1. Epub 2016 Oct 7.
8
In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction.人类精子在体外暴露于双酚A会诱导促氧化/凋亡性线粒体功能障碍。
Reprod Toxicol. 2016 Dec;66:61-67. doi: 10.1016/j.reprotox.2016.09.014. Epub 2016 Sep 26.
9
High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells.高内涵分析为双酚A及选定类似物对小鼠精原细胞的睾丸毒性提供了机制性见解。
Toxicol Sci. 2017 Jan;155(1):43-60. doi: 10.1093/toxsci/kfw178. Epub 2016 Sep 14.
10
Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome.双酚A暴露对患有多囊卵巢综合征的市场女摊主的代谢和内分泌影响。
Environ Sci Pollut Res Int. 2016 Dec;23(23):23546-23550. doi: 10.1007/s11356-016-7573-5. Epub 2016 Sep 10.
Zotero 插件