Charlton D E, Sephton R
Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
Int J Radiat Biol. 1991 Feb;59(2):447-57. doi: 10.1080/09553009114550401.
A method of calculating cell survival from microdosimetric spectra for high-LET radiations and exponential cell survival is discussed. The basis of the calculation is that a cell nucleus receiving a specific dose D has a probability of survival of exp(-D/Do), where Do, the specific lethal dose, is assumed to be independent of cell size and shape. A relationship between specific lethal dose and mean lethal dose is derived. This approach gives the result that mean lethal dose is sensitive to both cell size and shape (cells with disc-shaped and spherical nuclei are treated) and therefore its uses as an indicator of cell sensitivity at high LET must be viewed with caution.
本文讨论了一种根据高传能线密度（LET）辐射的微剂量谱计算细胞存活以及指数细胞存活的方法。计算的基础是，接受特定剂量D的细胞核具有exp(-D/Do)的存活概率，其中Do（特定致死剂量）被假定与细胞大小和形状无关。推导出了特定致死剂量与平均致死剂量之间的关系。该方法得出的结果是，平均致死剂量对细胞大小和形状均敏感（对具有盘状和球状细胞核的细胞进行了处理），因此在高LET条件下将其用作细胞敏感性指标时必须谨慎看待。
