Harder D, Virsik-Peuckert P
Br J Cancer Suppl. 1984;6:243-7.
A functional relationship determining the survival curve for reproductive cell death caused by low-LET radiation is derived on the basis of Lea's repair/interaction model. Radiation-induced primary lesions are assumed to interact pair-wise to form long-lived lethal lesions, simultaneously with the repair of the primary lesions. The formula derived for a short single irradiation gives a typical shouldered survival curve. At doses below the shoulder the interaction entirely occurs at low levels of primary lesion concentration, resulting in the parabolic shape of the logarithmic survival curve. At higher doses the interaction initially proceeds at high levels of primary lesion concentration, a state whose duration is determined by the dose and the finite speed of the first-order reaction of repair; this initial phase of the interaction results in the exponential tail of the survival curve. Survival after fractionated and protracted irradiation are also obtained. The dependence of cell survival on the irradiation conditions can be interpreted in terms of the basic parameters of the model.
基于利的修复/相互作用模型，推导了一个确定低传能线密度辐射导致生殖细胞死亡存活曲线的函数关系。假定辐射诱导的原初损伤两两相互作用形成长寿命致死性损伤，同时原初损伤进行修复。为单次短时间照射推导的公式给出了典型的具有肩区的存活曲线。在肩区以下剂量，相互作用完全发生在低水平的原初损伤浓度下，导致对数存活曲线呈抛物线形状。在较高剂量下，相互作用最初在高水平的原初损伤浓度下进行，该状态的持续时间由剂量和一级修复反应的有限速度决定；相互作用的这个初始阶段导致存活曲线的指数尾部。还得到了分次照射和持续照射后的存活情况。细胞存活对照射条件的依赖性可以根据模型的基本参数来解释。
