Vandvik Per Olav, Lydersen Stian, Farup Per G
Department of Medicine, Innlandet Hospital Health Authority, Gjøvik, Norway.
Scand J Gastroenterol. 2006 Jun;41(6):650-6. doi: 10.1080/00365520500442542.
To study the prevalence of irritable bowel syndrome (IBS) and its comorbidity in a Norwegian adult population.
In 2001, 11,078 inhabitants (aged 30-75 years) in Oppland County were invited to take part in a public health survey. A total of 4622 subjects (42%) completed the questionnaires on symptoms of IBS (Rome II criteria), comorbidity, health-care visits and medications. The impact of comorbidity on global health, working disability and use of health-care resources in subjects with IBS was explored by stepwise logistic regression.
The population prevalence of IBS was 388/4622 (8.4% (95% CI: 7.6-9.4%)) with a female predominance and an age-dependent decrease. The proportion who had consulted for IBS ranged from 51% among 30-year-olds to 79% in 75-year-olds (p=0.05). IBS was associated with musculoskeletal complaints (OR = 2.4-3.4 for six different items), fibromyalgia (OR = 3.6 [2.7-4.8]), mood disorder (OR = 3.3 (2.6-4.3)), reduced global health (OR = 2.6 (2.1-3.2)), working disability (OR = 1.6 (1.2-2.1)), more frequent health-care visits and use of medications (OR 1.7-2.3). When controlling for comorbidity, reduced global health (OR = 1.5 (1.1-2.0)) and use of alternative health care (OR = 1.7 (1.3-2.4)) remained associated with IBS. Severity of abdominal pain/discomfort was a predictor of having to seek a physician for IBS (OR = 1.3 (1.2-1.5)).
Symptoms of IBS were reported by 8% of Norwegian adults and had resulted in consultations with physicians for the majority in the long run. Subjects with IBS in the community were characterized by frequent somatic and psychiatric comorbidity. Their observed reduced health, working disability and increased use of health resources were largely explained by comorbid symptoms and disorders.
研究挪威成年人群中肠易激综合征（IBS）的患病率及其合并症情况。
2001年，邀请了奥普兰郡11078名年龄在30 - 75岁之间的居民参与一项公共卫生调查。共有4622名受试者（42%）完成了关于IBS症状（罗马II标准）、合并症、医疗就诊及用药情况的问卷调查。通过逐步逻辑回归分析探讨合并症对IBS患者总体健康、工作能力丧失及医疗资源使用的影响。
IBS的人群患病率为388/4622（8.4%（95%可信区间：7.6 - 9.4%）），女性居多且患病率随年龄增长而降低。因IBS咨询过医生的比例在30岁人群中为51%，在75岁人群中为79%（p = 0.05）。IBS与肌肉骨骼症状（6项不同症状的比值比为2.4 - 3.4）、纤维肌痛（比值比 = 3.6 [2.7 - 4.8]）、情绪障碍（比值比 = 3.3 (2.6 - 4.3)）、总体健康状况下降（比值比 = 2.6 (2.1 - 3.2)）、工作能力丧失（比值比 = 1.6 (1.2 - 2.1)）、更频繁的医疗就诊及用药（比值比1.7 - 2.3）相关。在控制合并症后，总体健康状况下降（比值比 = 1.5 (1.1 - 2.0)）及使用替代医疗服务（比值比 = 1.7 (1.3 - 2.4)）仍与IBS相关。腹痛/不适的严重程度是因IBS而必须就医的一个预测因素（比值比 = 1.3 (1.2 - 1.5)）。
8%的挪威成年人报告有IBS症状且从长远来看大多数人因此咨询过医生。社区中IBS患者的特点是频繁出现躯体和精神合并症。他们观察到的健康状况下降、工作能力丧失及医疗资源使用增加在很大程度上可由合并症状和疾病来解释。
