Preobrazhenskaya Maria N, Olsufyeva Eugenia N
Gause Institute of New Antibiotics, B. Pirogovskaya 11, Moscow 119021, Russia.
Antiviral Res. 2006 Sep;71(2-3):227-36. doi: 10.1016/j.antiviral.2006.04.008. Epub 2006 May 6.
Antiviral activity and other biological properties of two groups of polycyclic peptides are discussed. Antibiotics of the complestatin-kistamycin group have a structural motif similar to that of the peptide core of antibacterial antibiotics of the vancomycin-teicoplanin group though no amino acid component in the chloropeptin-kistamicin antibiotics is identical to an amino acid incorporated in the peptide core of the antibiotics of the vancomycin-teicoplanin group. Chloropeptins and the hydrophobic several derivatives of antibacterial antibiotics are inhibitors of HIV and some other viruses. They interfere with the viral (i.e. HIV) entry process. Chemical modifications of natural glycopeptide antibiotics led to the compounds with antiviral properties whereas antibacterial properties were lost. These glycopeptide aglycons derivatives can be envisaged as potential lead compounds for application as microbicides against sexual HIV transmission.
讨论了两组多环肽的抗病毒活性及其他生物学特性。柔红霉素-奇霉素组抗生素具有与万古霉素-替考拉宁组抗菌抗生素肽核心相似的结构基序，尽管氯肽素-奇霉素抗生素中的氨基酸成分与万古霉素-替考拉宁组抗生素肽核心中所含的氨基酸均不相同。氯肽素及抗菌抗生素的几种疏水衍生物是HIV和其他一些病毒的抑制剂。它们干扰病毒（即HIV）的进入过程。天然糖肽抗生素的化学修饰产生了具有抗病毒特性但失去抗菌特性的化合物。这些糖肽苷元衍生物可被视为用作预防性HIV性传播杀菌剂的潜在先导化合物。
