Keller Ray
Department of Biology, University of Virginia, Charlottesville, VA 22901, USA.
Development. 2006 Jun;133(12):2291-302. doi: 10.1242/dev.02406.
Here, I discuss selected examples of elongation in embryogenesis to identify common and unique mechanisms, useful questions for further work, and new systems that offer opportunities for answering these questions. Fiber-wound, hydraulic mechanisms of elongation highlight the importance of biomechanical linkages of otherwise unrelated cellular behaviors during elongation. Little-studied examples of elongation by cell intercalation offer opportunities to study new aspects of this mode of elongation. Elongation by oriented cell division highlights the problem of mitotic spindle orientation and the maintenance of cell-packing patterns in anisotropic force environments. The balance of internal cell-adhesion and external traction forces emerges as a key issue in the formation of elongate structures from compact ones by directed migration.
在此，我讨论胚胎发育过程中伸长的选定示例，以确定共同和独特的机制、对进一步研究有用的问题，以及为回答这些问题提供机会的新系统。纤维缠绕的液压伸长机制突出了伸长过程中原本不相关的细胞行为的生物力学联系的重要性。细胞插入伸长的研究较少的示例为研究这种伸长模式的新方面提供了机会。定向细胞分裂导致的伸长突出了有丝分裂纺锤体取向问题以及在各向异性力环境中细胞堆积模式的维持。内部细胞粘附力和外部牵引力的平衡成为通过定向迁移从紧凑结构形成细长结构的关键问题。
