色素沉着抑制剂、褪黑素、费德霉素及其类似物的合成、立体化学和生物学特性。
Synthesis, stereochemistry, and biological properties of the depigmenting agents, melanostatin, feldamycin and analogs.
作者信息
Imae K, Kamachi H, Yamashita H, Okita T, Okuyama S, Tsuno T, Yamasaki T, Sawada Y, Ohbayashi M, Naito T
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1991 Jan;44(1):76-85. doi: 10.7164/antibiotics.44.76.
PMID:1672126
Abstract
Syntheses of melanostatin and feldamycin have been completed from L-serine and L-threonine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells.
摘要
分别以L-丝氨酸和L-苏氨酸完成了褪黑素和费德霉素的合成，并确定了未知不对称碳原子的构型。还制备了费德霉素类似物，其中L-色氨酰类似物在抑制比基尼链霉菌和B16黑色素瘤细胞色素沉着方面最有效。
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