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褪黑素抑制素，一种新型黑色素合成抑制剂。制备、分离、化学性质、结构及生物活性。

Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity.

作者信息

Ishihara Y, Oka M, Tsunakawa M, Tomita K, Hatori M, Yamamoto H, Kamei H, Miyaki T, Konishi M, Oki T

机构信息

Bristol-Myers Squibb Research Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Jan;44(1):25-32. doi: 10.7164/antibiotics.44.25.

DOI:10.7164/antibiotics.44.25
PMID:1672125
Abstract

Melanostatin, a new antibiotic with melanin synthesis inhibitor activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.

摘要

褪黑素抑制素是一种具有黑色素合成抑制活性的新型抗生素，它是从链霉菌No. N924 - 2的发酵液中分离得到的。其结构通过光谱分析和降解实验得以确定。褪黑素抑制素强烈抑制比基尼链霉菌NRRL B - 1049和B16黑色素瘤细胞中的黑色素形成。

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