一种利用比基尼链霉菌筛选黑色素生物合成抑制剂的新方法。
A new screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis.
作者信息
Tomita K, Oda N, Ohbayashi M, Kamei H, Miyaki T, Oki T
机构信息
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1990 Dec;43(12):1601-5. doi: 10.7164/antibiotics.43.1601.
A novel screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis NRRL B-1049 as the indicator organism has been developed. Several known compounds, including tyrosinase inhibitors, were found to inhibit melanin production of S. bikiniensis on agar plates. This screening method was applied to fermentation broths of actinomycetes and several cultures with melanin biosynthesis inhibitory activity were found.
已开发出一种以比基尼链霉菌NRRL B - 1049作为指示生物的新型黑色素生物合成抑制剂筛选方法。在琼脂平板上，包括酪氨酸酶抑制剂在内的几种已知化合物被发现可抑制比基尼链霉菌的黑色素生成。该筛选方法应用于放线菌的发酵液，发现了几种具有黑色素生物合成抑制活性的培养物。
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