Jauhiainen T, Salo P, Niittynen L, Poussa T, Korpela R
Valio Ltd, Helsinki, Finland.
Eur J Clin Nutr. 2006 Nov;60(11):1253-7. doi: 10.1038/sj.ejcn.1602445. Epub 2006 May 24.
To investigate the cholesterol-lowering effects of a low-fat cheese enriched with plant stanol esters in mildly hypercholesterolaemic subjects, as part of their normal diet.
A randomized double-blind parallel-group study.
Valio Ltd, Helsinki.
Sixty-seven mildly hypercholesterolaemic volunteers (24 men, 43 women) participated in the study, which all of them completed.
The subjects were randomly assigned to the plant stanol ester group or the control group. During the 5-week intervention, the subjects in the stanol group consumed a cheese enriched with 2 g of plant stanols per day, and the subjects in the control group, a control cheese with no plant stanols.
In the stanol ester group, as compared to the control group, both serum total and low-density lipoprotein (LDL) cholesterol decreased significantly, that is, by 5.8% (-0.32 mmol/l, 95% CI -0.50 to -0.15 mmol/l, P < 0.001) and 10.3% (-0.36 mmol/l, 95% CI -0.53 to -0.18 mmol/l, P < 0.001), respectively. There were no significant changes in high-density lipoprotein cholesterol (HDL), triglycerides or apolipoprotein B concentrations between the groups.
Cheese enriched with 2 g of plant stanol in the form of fatty acid esters decreases serum total and LDL cholesterol significantly.
研究富含植物甾醇酯的低脂奶酪对轻度高胆固醇血症患者的降胆固醇作用，该研究为其正常饮食的一部分。
随机双盲平行组研究。
赫尔辛基的Valio有限公司。
67名轻度高胆固醇血症志愿者（24名男性，43名女性）参与了本研究，且全部完成。
受试者被随机分配到植物甾醇酯组或对照组。在为期5周的干预期间，甾醇组的受试者每天食用富含2克植物甾醇的奶酪，对照组的受试者食用不含植物甾醇的对照奶酪。
与对照组相比，甾醇酯组的血清总胆固醇和低密度脂蛋白（LDL）胆固醇均显著降低，分别降低了5.8%（-0.32 mmol/l，95%CI -0.50至-0.15 mmol/l，P<0.001）和10.3%（-0.36 mmol/l，95%CI -0.53至-0.18 mmol/l，P<0.001）。两组之间的高密度脂蛋白胆固醇（HDL）、甘油三酯或载脂蛋白B浓度没有显著变化。
以脂肪酸酯形式富含2克植物甾醇的奶酪可显著降低血清总胆固醇和LDL胆固醇。
