Plana Nuria, Nicolle Catherine, Ferre Raimon, Camps Jordi, Cos Rosa, Villoria Jesus, Masana Luis
Unitat Recerca Lipids and Arteriosclerosi, Hospital Universitari Sant Joan, Universitat Rovira and Virgili, Sant Llorenç, 43201, Reus , Spain.
Eur J Nutr. 2008 Feb;47(1):32-9. doi: 10.1007/s00394-007-0693-4. Epub 2008 Jan 14.
The number of hypercholesterolemic individuals who do not meet their cholesterol recommended targets is inappropriately high. The use of plant sterol-enriched foods could help in this clinical setting.
To evaluate the efficacy and side effects of plant sterol-enriched fermented milk in reducing LDL-cholesterol and increasing the number of patients who attain their therapeutic targets.
This was a multicentre, randomised, double-blind, placebo-controlled, parallel clinical trial. Eighty-three hypercholesterolemic patients that were not at therapeutic goals were studied. The patients received one 100 ml serving of either plain (control) low-fat or phytosterol enriched (1.6 g of free sterol equivalents) drinkable yogurt per day along with the main meal for 42 days. The principal variables were variation on LDL cholesterol (LDL-C) concentration and the number of patients achieving therapeutic goals after intervention.
Patients on phytosterols attained an average LDL-C reduction of more than 10% (12.2% after 3 weeks; 10.6% after 6 weeks) (P = 0.001; 95% CI: 4.03-19.00) regardless of statin therapy compared to the control group. About 50% of the subjects on phytosterols, as compared to 20% of controls, attained their LDL-C target values (<3.3 or <2.6 mmol/l for primary and secondary prevention, respectively) at the end of the study (P < 0.001). HDL-cholesterol (HDL-C) did not change and triglycerides (TG) were decreased by 14% (P < 0.018). The plasma sterols/total cholesterol ratio increased.
Plant sterol-enriched fermented milk significantly reduced LDL-C and increased the number of moderately hypercholesterolemic patients achieving therapeutic targets.
未达到胆固醇推荐目标的高胆固醇血症患者数量过高。食用富含植物甾醇的食物可能有助于改善这种临床情况。
评估富含植物甾醇的发酵乳在降低低密度脂蛋白胆固醇（LDL-C）以及增加达到治疗目标的患者数量方面的疗效和副作用。
这是一项多中心、随机、双盲、安慰剂对照的平行临床试验。研究了83名未达到治疗目标的高胆固醇血症患者。患者每天在主餐时饮用一份100毫升的普通（对照）低脂或富含植物甾醇（1.6克游离甾醇当量）的可饮用酸奶，持续42天。主要变量为干预后LDL胆固醇（LDL-C）浓度的变化以及达到治疗目标的患者数量。
与对照组相比，无论是否接受他汀类药物治疗，食用植物甾醇的患者LDL-C平均降低超过10%（3周后降低12.2%；6周后降低10.6%）（P = 0.001；95%置信区间：4.03 - 19.00）。在研究结束时，约50%食用植物甾醇的受试者达到了LDL-C目标值（一级和二级预防分别为<3.3或<2.6 mmol/l），而对照组为20%（P < 0.001）。高密度脂蛋白胆固醇（HDL-C）未发生变化，甘油三酯（TG）降低了14%（P < 0.018）。血浆甾醇/总胆固醇比值升高。
富含植物甾醇的发酵乳显著降低了LDL-C，并增加了达到治疗目标的中度高胆固醇血症患者数量。
