寡核苷酸匹配器：用于通过反义或小干扰RNA进行基因沉默的特定寡核苷酸序列的分析与选择。
OligoMatcher: analysis and selection of specific oligonucleotide sequences for gene silencing by antisense or siRNA.
作者信息
Mamidipalli SudhaRani, Palakal Mathew, Li Shuyu
机构信息
Department of Computer and Information Science, Indiana University - Purdue University Indianapolis, Indianapolis, Indiana, USA.
出版信息
Appl Bioinformatics. 2006;5(2):121-4. doi: 10.2165/00822942-200605020-00008.
UNLABELLED
OligoMatcher is a web-based tool for analysis and selection of unique oligonucleotide sequences for gene silencing by antisense oligonucleotides (ASOs) or small interfering RNA (siRNA). A specific BLAST server was built for analysing sequences of ASOs that target pre-mRNA in the cell nucleus. Tissue- and cell-specific expression data of potential cross-reactive genes are integrated in the OligoMatcher program, which allows biologists to select unique oligonucleotide sequences for their target genes in specific experimental systems.
AVAILABILITY
The OligoMatcher web server is available at http://shelob.cs.iupui.edu:18081/oligomatch.php. The source code is freely available for non-profit use on request to the authors.
CONTACT
Mathew Palakal (mpalakal@cs.iupui.edu) or Shuyu Li (li_shuyu_dan@lilly.com).
未标注
OligoMatcher是一个基于网络的工具，用于分析和选择用于通过反义寡核苷酸（ASO）或小干扰RNA（siRNA）进行基因沉默的独特寡核苷酸序列。构建了一个特定的BLAST服务器，用于分析靶向细胞核中前体mRNA的ASO序列。潜在交叉反应基因的组织和细胞特异性表达数据整合在OligoMatcher程序中，这使生物学家能够在特定实验系统中为其靶基因选择独特的寡核苷酸序列。
可用性
OligoMatcher网络服务器可在http://shelob.cs.iupui.edu:18081/oligomatch.php获取。源代码可应作者要求免费用于非营利目的。
联系方式
Mathew Palakal（mpalakal@cs.iupui.edu）或Shuyu Li（li_shuyu_dan@lilly.com）。
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