Minuz Pietro, Fava Cristiano, Cominacini Luciano
Department of Biomedical and Surgical Sciences, Section of Internal Medicine, University of Verona, Verona, Italy.
Br J Clin Pharmacol. 2006 Jun;61(6):774-7. doi: 10.1111/j.1365-2125.2006.02681.x.
Oxidative stress has been recognized as a key mechanism in the development of vascular damage, particularly atherosclerosis. In spite of substantial experimental evidence demonstrating reversal of endothelial dysfunction and prevention of atherosclerosis in experimental settings, no benefits have been observed in large clinical trials in which antioxidants have been given in high-risk patients for the prevention of cardiovascular events. Evaluation of the clinical relevance of the oxidative modification hypothesis requires identification of potential molecular targets of antioxidant interventions and effective antioxidant agents. Future research should necessarily consider quantification of interindividual variations in oxidative stress using appropriate biomarkers.
氧化应激已被公认为是血管损伤尤其是动脉粥样硬化发生发展的关键机制。尽管有大量实验证据表明在实验环境中抗氧化剂可逆转内皮功能障碍并预防动脉粥样硬化，但在针对高危患者给予抗氧化剂以预防心血管事件的大型临床试验中，并未观察到有益效果。评估氧化修饰假说的临床相关性需要确定抗氧化干预措施的潜在分子靶点以及有效的抗氧化剂。未来的研究必然要考虑使用合适的生物标志物来量化个体间氧化应激的差异。
