Hoeschen R J
Department of Medicine, St Boniface General Hospital, Winnipeg, Manitoba.
Can J Cardiol. 1997 Nov;13(11):1021-5.
To assess the evidence supporting the role of oxidative stress in the pathogenesis of atherosclerosis, endothelial dysfunction, platelet aggregation and heart failure, and to evaluate the status of antioxidant therapy in the clinical management of cardiovascular disease.
No attempt was made to provide insight into mechanisms of oxidative stress and the response to antioxidant intervention. Human studies were scrutinized for evidence that oxidative stress was present and whether antioxidant therapy provides clinical benefit.
There is ample evidence that oxidative stress is involved in the pathogenesis of atherosclerosis, endothelial dysfunction, platelet aggregation and heart failure. However, the extrapolation of this evidence to the use of antioxidant therapy in primary or secondary prevention of cardiovascular disease cannot be justified at this time.
评估支持氧化应激在动脉粥样硬化、内皮功能障碍、血小板聚集和心力衰竭发病机制中作用的证据，并评估抗氧化治疗在心血管疾病临床管理中的现状。
未试图深入探讨氧化应激机制及对抗氧化干预的反应。对人体研究进行了审查，以寻找氧化应激存在的证据以及抗氧化治疗是否具有临床益处。
有充分证据表明氧化应激参与动脉粥样硬化、内皮功能障碍、血小板聚集和心力衰竭的发病机制。然而，目前将该证据外推至抗氧化治疗在心血管疾病一级或二级预防中的应用尚无依据。
