与导管内乳头状黏液性肿瘤相比，人胰腺黏液性囊腺瘤具有独特的黏蛋白、细胞角蛋白和CD10表达特征。

Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.

作者信息

Handra-Luca A, Fléjou J-F, Rufat P, Corcos O, Belghiti J, Ruszniewski P, Degott C, Bedossa P, Couvelard A

机构信息

Service d'Anatomie Pathologique, Hôpital Beaujon, Clichy, France.

出版信息

Histopathology. 2006 Jun;48(7):813-21. doi: 10.1111/j.1365-2559.2006.02444.x.

DOI:10.1111/j.1365-2559.2006.02444.x

PMID:16722930

Abstract

AIMS

To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs).

METHODS AND RESULTS

Thirty MCAs of the pancreas were analysed for immunohistochemical expression of cytokeratin (CK) 7, CK20, MUC1, MUC2, MUC5AC and CD10 and were compared with 16 IPMAs. CK7 was expressed in all neoplasms. CK20 was significantly more frequent in MCAs compared with IPMAs (56.66% versus 18.75%, P = 0.027). MUC1 was more frequent in MCAs (40% versus 12.5%, P = 0.0915), whereas MUC5AC was significantly less frequent in MCAs (33.33% versus 100%). MUC2 was expressed in goblet cells of seven MCAs. In MCAs, CD10 was observed both in epithelial cells and in the ovarian-type stromal cells (24/30). Epithelial expression of CD10 was significantly lower in IPMAs (66.66% versus 6.25%, p = 0.0001).

CONCLUSIONS

MCA is characterized by a significantly greater frequency of expression of CK20 and CD10 when compared with IPMA, which preferentially expresses MUC5AC.

摘要

目的

与导管内乳头状黏液性肿瘤（IPMA）相比，检测良性黏液性囊腺瘤（MCA）中细胞角蛋白、上皮糖蛋白（黏蛋白）和糖蛋白CD10的表达情况。

方法与结果

对30例胰腺MCA进行细胞角蛋白（CK）7、CK20、MUC1、MUC2、MUC5AC和CD10免疫组化表达分析，并与16例IPMA进行比较。CK7在所有肿瘤中均有表达。与IPMA相比，CK20在MCA中表达明显更频繁（56.66%对18.75%，P = 0.027）。MUC1在MCA中更常见（40%对12.5%，P = 0.0915），而MUC5AC在MCA中明显较少见（33.33%对100%）。MUC2在7例MCA的杯状细胞中表达。在MCA中，上皮细胞和卵巢型间质细胞均观察到CD10表达（24/30）。CD10的上皮表达在IPMA中明显较低（66.66%对6.25%，p = 0.0001）。