Fukuhara Masayo, Matsumura Kiyoshi, Ansai Toshihiro, Takata Yutaka, Sonoki Kazuo, Akifusa Sumio, Wakisaka Masanori, Hamasaki Tomoko, Fujisawa Kiyoshi, Yoshida Akihiro, Fujii Koji, Iida Mitsuo, Takehara Tadamichi
Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College, Fukuoka, Japan.
Circ J. 2006 Jun;70(6):756-61. doi: 10.1253/circj.70.756.
Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function.
Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score >or=24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0+/-0.8 vs 22.9+/-0.5 m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score.
These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age.
老年受试者存在认知功能损害，因此本研究的目的是确定动脉僵硬度对认知功能的作用。
分别通过简易精神状态检查表（MMSE）和测量肱踝脉搏波速度（PWV）来评估认知功能和动脉僵硬度。在203名受试者（87名男性，116名女性）中研究了MMSE评分与PWV的横断面相关性，所有受试者均为85岁。正常MMSE组（MMSE评分≥24，n = 128）和MMSE受损组（MMSE评分<24，n = 75）之间的性别分布、收缩压和舒张压无差异。相比之下，MMSE受损组的PWV显著高于正常MMSE组（25.0±0.8 vs 22.9±0.5 m/s，p<0.05）。在多元回归分析中，PWV也与MMSE评分独立且显著相关。
这些结果表明，在高龄人群中，通过PWV评估的动脉僵硬度可预测认知功能。预防动脉粥样硬化可能在维持正常认知功能直至高龄方面发挥重要作用。
