Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Av. Princesa Isabel, 395 Santana, Porto Alegre, RS, 90620-001, Brazil.
Syst Rev. 2022 Aug 13;11(1):171. doi: 10.1186/s13643-022-02036-w.
Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of training (aerobic, resistance, and combined) on endothelial function and arterial stiffness in older adults.
This systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, and Web of Science. We will follow the PRISMA guidelines and PICOS framework. Studies involving both male and female older adults (≥60 years old) with or without comorbidities undergoing aerobic, resistance, and/or combined training compared to a control group (no exercise) will be eligible. We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of individual studies and GRADE to assess the strength of evidence. Statistical analyses will be conducted with RStudio for Windows (v1.3.959) using R package meta.
A systematic review and meta-analysis involving data from studies of older adults would deepen our understanding of vascular adaptations to exercise training in this population. It could provide new insights into how health providers can improve patient management and prevention of cardiovascular events in older adults.
PROSPERO 42021275451.
衰老本身是心血管事件的一个独立危险因素。它会促进血管功能障碍，而血管功能障碍与心血管疾病（CVD）的危险因素有关。运动可以调节血管功能参数，但对于不同训练方式（有氧运动、抗阻运动和结合运动）对老年人内皮功能和动脉僵硬的影响知之甚少。
本系统综述研究将包括从电子数据库 MEDLINE（PubMed）、Cochrane、LILACS、EMBASE 和 Web of Science 中选择的随机对照试验（RCT）。我们将遵循 PRISMA 指南和 PICOS 框架。研究对象为年龄在 60 岁及以上的男性和女性老年人（无论是否患有合并症），他们接受有氧运动、抗阻运动和/或结合运动训练，与对照组（不运动）进行比较。我们将使用 Cochrane 风险偏倚 2 工具（RoB 2）评估个体研究的质量，并使用 GRADE 评估证据的强度。统计分析将使用 RStudio for Windows（v1.3.959）和 R 包 meta 进行。
一项涉及老年人研究数据的系统综述和荟萃分析将加深我们对该人群运动训练对血管适应性的理解。它可以为健康提供者如何改善老年患者的管理和预防心血管事件提供新的见解。
PROSPERO 42021275451。
